Liver Health Test

5.0

Learn more about your risk for liver disease with this accurate, reliable liver health test.

This liver test gives you insight into how your largest internal organ is functioning. From metabolizing toxins and fighting illness—to producing vital proteins and st... Read More

$79

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Liver Health Test

$79

Test Details

Sample Type: Blood

Collection Method: In person at a Labcorp location

Age: 18+

Results: 1 day from when your sample arrives at our lab

HSA/FSA: Accepted

Test must be taken by purchaser

Preparation: No special preparation is needed.

What's Tested

Bilirubin

A waste product produced by the liver as it breaks down red blood cells.
Total Protein

The total amount of proteins (including albumin) found in the blood that helps determine overall nutritional status.
Albumin

The main protein that circulates in the blood.
Alanine Aminotransferase (ALT)

An enzyme found mostly in the cells of the liver and kidney.
Aspartate Aminotransferase (AST)

An enzyme found in the cells throughout the body but primarily in the cells of the liver.
Alkaline Phosphatase

An enzyme found in the cells of the liver and other tissue.
Platelets

Blood cells that help your body form clots to stop bleeding.
FIB-4

A score calculated based on age, platelet count, AST and ALT levels to detect liver fibrosis.

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You may already be at risk

According to researchers, 1 in 4 people are affected by NAFLD. NAFLD is associated with obesity, type 2 diabetes and insulin resistance. This test determines if you’re at risk for liver damage (specifically liver fibrosis or liver scarring) connected to other cardiometabolic conditions² you may have, and can give your healthcare provider valuable insights to inform your care.

When caught in the early stages of disease, NAFLD and even NASH can sometimes be reversed – the earlier you know your risk factors or indicators of a disease, the sooner you can get the care you need.

Healthy habits for a healthy you

Assessing your liver health is an important step in taking care of your body. Habits such as exercise, your diet, or drinking too much can all have different impacts on the health of your liver. This liver health test gives key insights to get you on the right track on the journey to a healthier you.

Based on the latest guidelines

The American College of Gastroenterology, American Association of Clinical Endocrinology, and the American Diabetes Association recommend the FIB-4 calculation score as a simple, accurate, noninvasive initial screening test for those with certain risk factors for liver fibrosis:

· Obesity

· Metabolic syndrome

· Type 2 Diabetes or prediabetes

· Hepatic steatosis (evidence of fatty liver) on any imaging study

· Elevated ALT or AST levels (persistent for over 6 months)

In conjunction with this test, those with significant risk factors should be screened for NAFLD and advanced fibrosis under the guidance of a health care provider.

1. National Institutes of Health (NIH). Definition & Facts of NAFLD & NASH. Last reviewed April 2021. Accessed May 15, 2023.https://www.niddk.nih.gov/health-information/liver-disease/nafld-nash/definition-facts.

2. American Heart Association. About Metabolic Syndrome. www.heart.org. 2016. Accessed May 15, 2023. https://www.heart.org/en/health-topics/metabolic-syndrome/about-metabolic-syndrome.

3. Rinella ME, Lazarus JV, Ratziu V, et al. A multi-society Delphi consensus statement on new fatty liver disease nomenclature. Hepatology. 2023.

3. Cusi K, Isaacs S, Barb D, et al. American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings: Co-Sponsored by the American Association for the Study of Liver Diseases (AASLD). Endocr Pract. 2022;28(5):528-562. doi:10.1016/j.eprac.2022.03.010

4. ElSayed NA, Aleppo G, Aroda VR, et al. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Care in Diabetes—2023. Diabetes Care. 2022;46(Supplement_1):S49-S67. doi: https://doi.org/10.2337/dc23-s004

5. Nassir F, Rector RS, Hammoud GM, Ibdah JA. Pathogenesis and Prevention of Hepatic Steatosis. Gastroenterol Hepatol. 2015;11(3):167-175.

What Does This Test Measure?

The Liver Health Test informs you about your estimated risk of liver fibrosis (scar tissue). Using a combination of your age and blood test results, the FIB-4 calculation generates a number, or a “score.” This score can help you and your healthcare provider determine your risk of developing liver fibrosis which is a potential complication of a variety of liver conditions including NAFLD, Hep B, Hep C and others.

While the FIB-4 test does not measure other factors that are important for the diagnosis of NAFLD and NASH¹, it’s an excellent starting point for discussion with your provider and can help get you on the right track if further testing and evaluation is needed.

Like many diseases, the names and descriptions used can change over time. It should be noted that the terminology for NASH and NAFLD are in the process of being updated to better reflect the underlying cause of the disease.³ You may see or hear Metabolic dysfunction-associated steatohepatitis (MASH) and metabolic dysfunction-associated steatotic liver disease (MASLD) being used by your healthcare provider.

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Purchase Your Test

Simply purchase this test online. A healthcare provider will review and approve your test requests; no healthcare provider visit is required.

Provide Your Sample

Visit a Labcorp location near you for sample collection. Visits may be scheduled online.

Get Your Results

View your easy-to-read results online in your Labcorp Patient™ account, including Linked Accounts. For certain results that require prompt attention, you will also be contacted by phone or mail.

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Diverse group of middle-aged adults discussing liver health.

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FAQ

If you are wondering about your current liver health status, this test may be right for you.

If you have risk factors for MASLD (previously NAFLD) or MASH (previously NASH) such as:
• Obesity
• Prediabetes
• Type 2 diabetes

• More than two of the following features of metabolic syndrome:
                -High blood glucose (sugar)

                -Low levels of HDL (“good”) cholesterol

                -Excess body fat around the waist

                -High levels of triglycerides (a type of “bad” cholesterol)

                -High blood pressure⁴

Speak with your healthcare provider about your risk based on these and other factors.

MASLD (previously NAFLD) or MASH (previously NASH) are considered “silent” diseases because often symptoms may not appear until disease has progressed. That’s why it’s important to screen if you’re at risk for MASLD or MASH.

Note: The FIB-4 score was originally developed and validated in patients between 35 and 65 years of age. There may be a higher risk of false positive results in those greater than 65 years old given that age is part of the calculation. You should speak with your provider about your results.
Abnormal results may indicate that your liver is not working properly and signals potential health problems. You should consult with your health care provider with any abnormal results and/or if you are experiencing concerning symptoms.

Bilirubin Results: Low levels may be due to taking medications such as antibiotics, oral contraceptives, seizure medications. High levels may be a sign of liver or gallbladder disease, or excessive breakdown of red blood cells, among other conditions.

Total Protein Results: Age, diet, hydration and stress can affect protein levels, but high or low levels may also be a sign of inflammation, liver disease, and other health conditions.

Albumin Results: Low levels may be a sign of malnutrition, infection, or liver, thyroid, or kidney disease, among other conditions. Higher than normal levels of albumin could be a result of dehydration.

ALT Results: High levels could be a sign of liver damage or infection, among other conditions.

AST Results: High levels could be a sign of liver damage or liver inflammation, among other conditions.

Alkaline Phosphatase Results: High levels of ALP have various potential causes and may be a sign of liver, gallbladder, or bone disease.

Platelet Results: Low levels can lead to bleeding risk and may be due to a variety of causes, such as liver disease, infections, certain medications (such as aspirin, H2 blockers, quinidine, sulfa antibiotics, some diuretics), or bone marrow disorders. High levels may be caused by inflammation, anemia or a bone marrow disorder, among other causes.

FIB-4 Score and Results:
    A FIB-4 score between 0 – 1.29 indicates a low risk for advanced liver fibrosis.
    A FIB-4 score between 1.30 – 2.67 indicates an indeterminate or moderate risk for advanced liver fibrosis. You should follow up with your health care provider. Your health care provider may recommend additional tests such as imaging for further assessment.
    A FIB-4 score greater than 2.67 indicates a high risk for advanced fibrosis and for development of other liver-related complications. You should follow up with your health care provider. Your health care provider may recommend additional tests such as imaging and/or refer you to a liver specialist for further work up, which may include a liver biopsy.

Abnormal liver function due to MASLD is common in diabetes. People with prediabetes, type 2 diabetes, obesity, dyslipidemia, metabolic syndrome and/or hypertension have a higher risk of developing MASLD and MASH. No single test can diagnose MASLD or MASH (a provider makes this clinical diagnosis).

This test is not intended to diagnose any liver disease or condition associated with liver disease. Knowing your risk is the first step to taking control of the disease.
It may take years for symptoms to develop, but eventual symptoms may include:

Fatigue
Abdominal discomfort
Jaundice (skin yellowing)
Generalized itching

Because these symptoms are commonly associated with a number of other conditions, early screening is vital to early intervention.
Because cardiometabolic diseases like MASLD (previously NAFLD), MASH (previously NASH), diabetes, cardiovascular disease and heart disease cover a wide range of organs and systems, you are encouraged to discuss testing with your provider and/or consider taking a comprehensive metabolic panel (CMP) test. A CMP test measures key enzymes in your blood for valuable information on your metabolism, liver and kidneys, including:

Glucose (blood sugar)
Calcium
Total protein
Sodium
Potassium
Tests related to your kidneys and liver health
eGFR (a calculation based on a few factors that estimates your kidney function)

Labcorp OnDemand offers a convenient CMP that you can order today. Share the results of this test with your provider to determine if further tests or examinations are necessary.
There are things you can start doing now to reduce your risk of liver disease and other health issues. This includes adopting or maintaining a healthier lifestyle:

Maintaining a healthy weight (even a 3-10% reduction in total body weight can make an impact)
Eat a well-balanced diet
Reducing total cholesterol levels
Control diabetes

Stop or cut back on drinking alcohol
Exercise regularly
Are there medications or supplements that can hurt my liver?
Do I need further testing based on my results?
What are my treatment options?
What are the benefits and risks of different tests or treatments?
Is there anything I can do myself to stop the disease from getting worse?
Your results will be provided to you through our secure online portal to view or print. Results are also made available through a secure portal to the independent healthcare provider who placed your test order. If you are accessing your results through your Labcorp Patient™ account, all users linked to the account will have access to all OnDemand test results. Results may also be provided to a local, state, and/or federal health authority; for example, many states require the testing laboratory and physician to report test results for certain communicable diseases, such as COVID-19, to local or state health departments.

If you have questions or comments regarding the Labcorp Notice of Privacy Practices, or have a complaint about our use or disclosure of your PHI or our privacy practices, please contact: privacyofficer@labcorp.com, call us at (877) 234-4722 (877-23-HIPAA) and ask for the Labcorp HIPAA Privacy Officer, or send a written request to: HIPAA Privacy Officer, Labcorp, 531 South Spring Street, Burlington, NC 27215. You also may file a complaint with the Secretary of the U.S. Department of Health and Human Services.
Visit the Labcorp OnDemand® website to browse and purchase laboratory tests and create your Labcorp Patient™ account to view your results. All Labcorp OnDemand testing requires an order from an authorized healthcare professional. For your convenience, Labcorp OnDemand has contracted with independent professional entities (collectively, Providers) to deliver healthcare provider services. Visit a Labcorp location for sample collection; or, if using an at-home collection kit, collect your sample yourself. We’ll let you know when your results are ready and can be accessed through your Labcorp Patient™ account.

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Reviews

L. P.

Verified Customer

June 28, 2025

Simple and convenient

Took this test at my local Labcorp location. It was easy to order and to make an appointment. The Labcorp location was convenient enough and the staff was wonderful even though they were quite busy. I received my results in less than 24 hours. I will... Read More

Anonymous

Verified Customer

May 11, 2025

Very Positive Experience

I greatly appreciate the ease of signing in for the test, the convenient location, and the patience and expertise of Ebony, the lab technician; I am pleased with the entire experience. Thank you, Labcorp.

Anonymous

Verified Customer

March 17, 2025

Easy and Cost Effective

The test was done at my local Labcorp office. It was very easy to schedule at a time I needed. The experience, once I arrived, was quick and relatively pain free. I ordered the test on-line because it was much cheaper than going to the doctor (being... Read More

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Liver Health Test

Learn more about your risk for liver disease with this accurate, reliable liver health test.

Test Details