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Estradiol (E2) Test

$ 69.0

Empower yourself with answers about your estrogen level.

As the hormone responsible for developing and regulating the female reproductive system, estradiol (E2) plays an important role in the menstrual cycle, supporting pregnancy and maintaining reproductive health.


Low estradiol levels can impact your bones, brain, cardiovascular and reproductive health. If you are experiencing symptoms of dry skin, trouble concentrating, hot flashes, mood swings and menstrual changes, you may have low levels of estradiol.  


The Labcorp OnDemand Estradiol (E2) Test measures the levels of estradiol in your blood to provide insights into your hormone health.


Note: This test does not diagnose or determine the cause of infertility. It is recommended to consult with a healthcare provider if you have any questions about your result.

Estradiol (E2) Test
$ 69.0

Test Details

Sample Type: Blood
Collection Method: In person at a Labcorp location
Age: 18+
Results: 1 day from when your sample arrives at our lab
HSA/FSA: Accepted
Test must be taken by purchaser

Preparation: If you are still menstruating, it is recommended to test on day 3 of your menstrual cycle (cycle day 1 is the first day of your period). If you have no menstrual cycle or have irregular menstrual cycles, you can test at any time.

If you’re taking a supplement containing biotin (also called vitamin B7 or B8, vitamin H or coenzyme R), commonly found in products promoting nail, skin and hair health, we recommend that you wait at least 72 hours from your last dose before taking the test.

What's Tested
  • Estradiol (E2)

    Produced by the ovaries, estradiol is the most common type of estrogen. It regulates menstrual cycles in women and helps thicken the lining of the uterus. Estradiol levels fluctuate throughout the menstrual cycle, peak right before ovulation, and drop after ovulation occurs. 

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  • The Labcorp OnDemand Estradiol Test measures the level of estradiol, a type of estrogen also known as E2, in your blood.


    As estradiol plays a major role on the reproductive system, this E2 test will assess your estradiol hormone level and provide further insights into reproductive health and any signs of a hormonal imbalance. This test can provide baseline insight into menstrual cycle issues or hormonal symptoms (such as irregular periods, decreased sex drive or weight fluctuation) that you may be experiencing.


    Estradiol level will vary based on several factors including your age and if you are taking certain medications (such as birth control).


    Note: This E2 test does not diagnose or determine the cause of infertility. Estradiol is typically evaluated in the context of other hormone levels such as follicle-stimulating hormone. It is recommended to consult with a healthcare provider if you have any questions about your result.


    This test is not intended for individuals on hormone therapy or hormonal contraception, as these may interfere with the test results. Hormone levels may fluctuate widely throughout the menstrual cycle, especially during pregnancy and the menopause transition.

  • For those assigned female at birth: We recommend that you test on day three of your menstrual cycle (cycle day one is the first day of your period). Since estradiol levels fluctuate throughout the menstrual cycle, results will vary on any given day. Day 3 of your menstrual cycle is considered the “baseline” because that's typically when estradiol levels are most stable.


    If you have irregular menstrual cycles, you can test at any time.

  • Estrogen levels fluctuate throughout life, including puberty, fertility and menopause. As you age, estrogen levels begin to decline naturally. If you have concerns about fertility or menopause, more comprehensive tests could be considered, including Fertility Ovarian Reserve Test and Menopause Test.

  • Adults assigned female at birth may experience symptoms of hormonal imbalances or fluctuations during menopausal transition such as:

    • Fatigue
    • Difficulty sleeping
    • Loss of interest in sex
    • Irregular or no menstrual periods
    • Heavy menstrual periods
    • Hot flashes
    • Weight gain
    • Mood changes


    If you’re experiencing new, persistent symptoms or have concerns about your estradiol levels, it’s best to consult with a healthcare provider who can interpret the results in the context of your overall health and medical history.

  • Hormone changes in the body trigger each of the four phases of the menstrual cycle: menstruation, follicular phase, ovulation and luteal phase.


    Menstruation is the first phase of the menstrual cycle and is the shedding of lining of the uterus. During menstruation, the levels of the hormones estrogen and progesterone drop, which causes the endometrium to detach from the walls of the uterus and bleed.


    Proliferative (follicular) phase is the phase of the menstrual cycle that starts after menstruation and ends with ovulation. During this phase, the ovaries produce follicles which develop into a mature egg. The level of estrogen increases, and this helps to thicken the lining of the uterus so that it can support a pregnancy. The follicles grow and mature under the influence of follicle-stimulating hormone (FSH).


    Ovulation phase is when an egg is released from a follicle in the ovary. Ovulation is triggered by a surge in the hormone luteinizing hormone (LH). The egg travels down the fallopian tube towards the uterus, where it can be fertilized by a sperm.


    Luteal phase begins after ovulation where the follicle that released the egg becomes a corpus luteum, which produces progesterone. Progesterone helps to maintain the thick lining of the uterus to prepare for a fertilized egg. If fertilization does not occur, the corpus luteum breaks down and the level of progesterone decreases. This causes the lining of the uterus to shed, and the menstrual cycle begins again.

  • Want to learn more about estradiol testing, hormonal imbalance or key hormones in women? Here are some additional resources to help you stay informed about your hormone health:

  • Your testing will be performed in a CLIA-certified clinical laboratory. Labcorp provides leading-edge medical laboratory tests and services through a national network of primary clinical laboratories and specialty testing laboratories. Our labs perform regular quality assurance testing to ensure our results are accurate.

  • Your results will be provided to you through our secure online portal to view or print. Results are also provided to PWNHealth, which provides professional healthcare provider services for OnDemand tests. If you are accessing your results through your Labcorp Patient account, all users linked to the account will have access to all OnDemand test results. Results may also be provided to a local, state, or federal health authority, but only when legally required. For example, many states require the testing laboratory and healthcare provider to report test results for certain communicable diseases, such as sexually transmitted diseases or COVID-19, to local or state health departments.  


    If you have questions or comments regarding the Labcorp Notice of Privacy Practices, or have a complaint about our use or disclosure of your PHI or our privacy practices, please contact: [email protected], call us at (877) 234-4722 (877-23-HIPAA) and ask for the Labcorp HIPAA Privacy Officer, or send a written request to: HIPAA Privacy Officer, Labcorp, 531 South Spring Street, Burlington, NC 27215. You also may file a complaint with the Secretary of the U.S. Department of Health and Human Services.

  • Visit the Labcorp OnDemand website to browse and purchase laboratory tests and create your Labcorp OnDemand account. All Labcorp OnDemand testing requires a healthcare provider order; for your convenience, Labcorp OnDemand has contracted with PWNHealth LLC and its affiliated professional entities (collectively, PWNHealth) to provide healthcare provider services. Visit a Labcorp location for sample collection; or, if using an at-home kit, collect your sample yourself. We’ll let you know when your results are ready to be accessed through your Labcorp OnDemand account or through your Labcorp Patient account.