Celiac Disease Antibody Test

Sample Type:
Sample Type
Age: 18+
Collection Method: Visit a Labcorp Location
HSA/FSA Accepted
Short Description

Help determine if your discomfort from consuming gluten is caused by celiac disease.


Celiac disease is an autoimmune disorder caused by an immune response to gluten consumption that can lead to gastrointestinal (GI) discomfort, loose stools, weight loss, and other symptoms. If you are seeking guidance and answers because you think you may have the disease, then this screening test is for you. Our Celiac Disease Antibody Test is the first step in determining whether you may have celiac disease, providing the answers you need to take control of your health from the lab that doctors trust most.

This screening test detects and measures antibodies your body may produce as an immune response after you consume gluten, if you have celiac disease.

What Does This Test Measure?

This test measures your total immunoglobulin A (IgA) and IgA antibodies to tTG (tissue transglutaminase). If your total IgA levels are low or deficient, a second test is conducted to examine levels of IgG antibodies to tTG (tissue transglutaminase) and IgG antibodies to DGP (deamidated gliadin peptide).



This test is not intended for patients already on a gluten-free diet.

You should see your healthcare provider for evaluation before considering this test if you have any concerning symptoms such as blood in your stool, fever, unusual weight loss, excessive diarrhea, or abdominal pain.

Why Consider This Test


Labcorp's Celiac Disease Antibody Test follows American College of Gastroenterology guidelines by measuring tTG-IgA and total IgA, and if necessary, a second test will be performed to measure tTG-IgG and DGP-IgG.1

Family Screening Matters

First-degree relatives of people with celiac disease (parents, siblings and children) have a 1 in 10 risk compared to 1 in 100 in the general population.2

Silent Symptoms

Some people do not experience any obvious symptoms related to celiac disease, but nevertheless undergo an immune response that causes damage to the small intestine (villous atrophy).3

Trusted by Doctors

Sample collection is conducted at a Labcorp patient service center near you and processed in the same labs that hospitals and physicians trust and use.

How It Works

1. Choose your tests

Shop for tests and pay online. An independent physician will review and approve your test requests; no doctor’s visit is required.




2. Provide Your Sample

Take the requisition number we emailed you, along with a photo ID, to a Labcorp location for sample collection.




3. Access your results online

View your easy-to-read results online in your OnDemand or Labcorp Patient™ accounts, including Linked Accounts (click here for more details). For certain results that require prompt attention, you will also be contacted by PWN health via phone or mail. 



Frequently Asked Questions

    Celiac disease is an autoimmune disease in which the ingestion of gluten leads to damage in the small intestine. When people with celiac disease eat gluten (a protein found in wheat, rye, and barley), their body mounts an immune response that attacks and damages the small intestine, causing nutrients to not be absorbed properly into the body. Celiac disease is hereditary; people with a particular genetic makeup are susceptible to developing celiac disease at any age.4, 5

    Celiac disease affects people differently with a wide variety of potential symptoms. People may experience digestive symptoms or symptoms in other parts of the body. The most common symptoms include abdominal pain, bloating and gas, constipation, diarrhea, fatigue, headaches or migraines, iron-deficiency anemia and weight loss. However, some may experience no symptoms at all but are nonetheless at risk if they remain undiagnosed and untreated.6

    Find out if you have an increased risk for celiac disease with the Celiac Disease Foundation’s symptoms assessment tool.

    Adults concerned they may have celiac disease, first-degree relatives of people with celiac disease, and individuals with an associated autoimmune disorder or other condition, especially Type 1 diabetes mellitus, autoimmune thyroid disease, autoimmune liver disease, Down syndrome, Turner syndrome, Williams syndrome, and selective immunoglobulin A (IgA) deficiency should be tested for celiac disease.4

    Celiac disease can be serious, and being undiagnosed and untreated with a gluten-free diet can cause long-term complications such as anemia, malnutrition, poor bone health, and increased risk of other autoimmune disorders. 7

    Labcorp’s Celiac Disease Antibody Test is the first step in screening for celiac disease. Our test screens for celiac disease by measuring your antibody levels. If your results suggest celiac disease is possible or likely, talk to your healthcare provider who may consider further testing in order to diagnosis celiac disease with a small bowel biopsy.

    Symptoms for both celiac disease and non-celiac gluten sensitivity can be similar to one another and may be improved by a gluten-free diet. However, only people with celiac disease will test positive for antibodies specific to the autoimmune disorder involving inflammation and damage to the small intestine.8

    • Total IgA: IgA is a class of antibody that is found throughout your body, especially in the GI tract and is involved in many of your immune responses. If your IgA levels are low or deficient, additional testing will be done to further screen your risk of celiac disease.
    • tTG-IgA: This is the primary screening test used to detect IgA antibodies to tTG (tissue transglutaminase).
    • tTG-IgG: This test detects IgG antibodies to tTG (tissue transglutaminase), and will be performed only if your IgA level is low or deficient.
    • DGP-IgG: This test measures IgG antibodies to DGP (deamidated gliadin peptide) and will be performed only if your IgA level is low or deficient.


    When taking this test, it is important to currently have gluten in your diet in order for accurate testing and results. If you have celiac disease and are on a gluten-free diet for two or more weeks, your celiac antibodies will decrease over time and may be undetectable.

    If your results suggest celiac disease is possible or likely, you should share your results and any symptoms you are having with your healthcare provider. Your healthcare provider can determine if additional testing is necessary and discuss next steps on how to improve your health and wellness.

    If your initial results indicate celiac disease is unlikely but you have a first-degree relative with celiac disease, it is reasonable to repeat this celiac antibody test in 4-5 years because celiac disease can develop at any age in people who are genetically susceptible. 9


    1. The American Journal of Gastroenterology, ACG: Clinical Guidelines: Diagnosis and Management of Celiac Disease, https://journals.lww.com/ajg/Fulltext/2013/05000/ACG_Clinical_Guideline…

    2. Celiac Disease Foundation. Testing and Diagnosis. Accessed September 20, 2022. https://celiac.org/about-celiac-disease/screening-and-diagnosis/screeni…

    3. Celiac Disease Foundation. Symptoms of Celiac Disease. Accessed September 20, 2022. https://celiac.org/about-celiac-disease/symptoms-of-celiac-disease/

    4. Celiac Disease Foundation. What is Celiac Disease. Accessed September 20, 2022. https://celiac.org/about-celiac-disease/what-is-celiac-disease/

    5. Taylor AK, Lebwohl B, Snyder CL, Green PHR. Celiac Disease. 2008 Jul 3 [updated 2019 Jan 31]. In: Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2022. PMID: 20301720.

    6. National Institute of Diabetes and Digestive and Kidney Diseases. Celiac Disease. Accessed September 20, 2022. https://www.niddk.nih.gov/health-information/digestive-diseases/celiac-…

    7. Cosnes J, Cellier C, Viola S, Colombel JF, Michaud L, Sarles J, Hugot JP, Ginies JL, Dabadie A, Mouterde O, Allez M, Nion-Larmurier I; Groupe D'Etude et de Recherche Sur la Maladie Coeliaque. Incidence of autoimmune diseases in celiac disease: protective effect of the gluten-free diet. Clin Gastroenterol Hepatol. 2008 Jul;6(7):753-8. doi: 10.1016/j.cgh.2007.12.022. Epub 2008 Feb 6. PMID: 18255352.

    8. Celiac Disease Foundation. Non-Celiac Gluten/Wheat Sensitivity. Accessed September 20, 2022. https://celiac.org/about-celiac-disease/related-conditions/non-celiac-w…

    9. Goldberg D, Kryszak D, Fasano A, Green PH. Screening for celiac disease in family members: is follow-up testing necessary? Dig Dis Sci. 2007 Apr;52(4):1082-6. doi: 10.1007/s10620-006-9518-1. Epub 2007 Feb 16. PMID: 17380406.