The Comprehensive Heart Health Panel is an advanced blood test that provides important insights into your cardiovascular health. This comprehensive panel measures multiple biomarkers associated with heart disease risk, offering a more complete picture of your heart health and helping to identify potential risk factors for heart disease before symptoms appear.
Note: This test is not intended to diagnose CVD, Type 2 diabetes, or other diseases.
Preparation: Fast for 12-14 hours (no food or drink, except water) before sample collection.
This test measures the number of low-density lipoprotein particles (LDL-P) circulating in the body, using nuclear magnetic resonance (NMR) technology. LDL cholesterol is known as the “bad” cholesterol because LDL particles can build up in the walls of your arteries, which increases the risk of heart attack and stroke. In addition, this NMR blood test includes a standard lipid panel (total cholesterol, calculated LDL cholesterol, HDL cholesterol, triglycerides) and an insulin resistance score to provide a more detailed analysis of cardiovascular risk.
This test measures the level of lipoprotein(a) in your blood, a type of “bad” cholesterol that is associated with an increased risk of heart disease and other cardiovascular conditions Lp(a) levels are often genetically determined and high Lp(a) levels run in families.
ApoB is the major protein on LDL particles which carry substances in your blood that help make plaque, a waxy fat that can block your arteries. An ApoB test measures the amount of ApoB in the blood. An elevated level of ApoB may indicate an increased risk for cardiovascular disease.1
This test measures an enzyme called lipoprotein-associated phospholipase A2 (Lp-PLA2) in your blood, which is a marker of active inflammation in your arteries or blood vessels. An elevated Lp-PLA2 level may indicate a higher risk of developing heart disease and stroke.
GlycA is a biomarker of systemic inflammation and cardiometabolic risk that measures levels of glycosylated acute-phase proteins. Elevated levels of GlycA have been associated with a higher risk of various conditions, including cardiovascular disease and diabetes. GlycA can be a predictor of chronic inflammation, which is known to contribute to the development of these diseases.2
DRI is a biomarker score for insulin resistance and evaluates factors that contribute to your risk of developing Type 2 diabetes. This insulin resistance test goes beyond measuring blood sugar. It analyzes specific lipids (lipoproteins) and certain amino acids that are linked to insulin resistance. By combining these results, this test creates a score that healthcare providers can use to assess your risk of developing Type 2 diabetes. This is especially helpful for people with normal blood sugar levels, as it can identify those who might be at higher risk despite not yet showing classic symptoms. A higher DRI score can indicate a higher risk of developing Type 2 diabetes.3
This test measures (at high sensitivity) the level of C-reactive protein: a substance made by the liver in response to inflammation. Elevated CRP levels are associated with several diseases and conditions including chronic inflammation, heart disease, diabetes, rheumatoid arthritis and cancer.
This expanded panel provides a more thorough evaluation of your cardiovascular health than standard lipid tests. It measures advanced biomarkers that can offer deeper insights into your cardiovascular risk, allowing for more informed decisions about your health and lifestyle.
By understanding your levels for key heart health indicators, you can take proactive steps to manage your health for a longer, healthier life. This heart health panel can help you and your healthcare provider detect early signs of cardiometabolic conditions such as abnormal lipid levels, insulin resistance and systemic inflammation, empowering you to address these risks with lifestyle changes and preventive treatments.
If you have a family history of cardiovascular conditions or diabetes, or if you have had a previous cardiovascular event, you may be at higher risk of cardiovascular disease or Type 2 diabetes. This expanded heart health test can detect early indicators of heart disease and help in proactively managing potential risks.
1. Devaraj S, Semaan JR, Jialal I. Biochemistry, Apolipoprotein B. In: StatPearls. Treasure Island (FL): StatPearls Publishing; May 14, 2023.
2. Ballout RA, Remaley AT. GlycA: A new biomarker for systemic inflammation and cardiovascular disease (CVD) risk assessment. J Lab Precis Med. 2020;5:17. doi:10.21037/jlpm.2020.03.03
3. Flores-Guerrero JL, Gruppen EG, Connelly MA, et al. A Newly Developed Diabetes Risk Index, Based on Lipoprotein Subfractions and Branched Chain Amino Acids, is Associated with Incident Type 2 Diabetes Mellitus in the PREVEND Cohort. J Clin Med. 2020;9(9):2781. Published 2020 Aug 27. doi:10.3390/jcm9092781
4. Centers for Disease Control and Prevention. About lipoprotein(a). Accessed June 9, 2025. https://www.cdc.gov/heart-disease-family-history/about/about-lipoprotein-a.html
5. Centers for Disease Control and Prevention. Heart Disease Risk Factors. Accessed June 9, 2025. https://www.cdc.gov/heart-disease/risk-factors/index.html
<p>1. Devaraj S, Semaan JR, Jialal I. Biochemistry, Apolipoprotein B. In: <i>StatPearls</i>. Treasure Island (FL): StatPearls Publishing; May 14, 2023.</p> <p>2. Ballout RA, Remaley AT. GlycA: A new biomarker for systemic inflammation and cardiovascular disease (CVD) risk assessment. <i>J Lab Precis Med.</i> 2020;5:17. doi:10.21037/jlpm.2020.03.03</p> <p>3. Flores-Guerrero JL, Gruppen EG, Connelly MA, et al. A Newly Developed Diabetes Risk Index, Based on Lipoprotein Subfractions and Branched Chain Amino Acids, is Associated with Incident Type 2 Diabetes Mellitus in the PREVEND Cohort. <i>J Clin Med</i>. 2020;9(9):2781. Published 2020 Aug 27. doi:10.3390/jcm9092781</p> <p>4. Centers for Disease Control and Prevention. About lipoprotein(a). Accessed June 9, 2025. <a href="https://www.cdc.gov/heart-disease-family-history/about/about-lipoprotein-a.html" target="_blank" title="about-lipoprotein-a" rel="noopener noreferrer">https://www.cdc.gov/heart-disease-family-history/about/about-lipoprotein-a.html</a></p> <p>5. Centers for Disease Control and Prevention. Heart Disease Risk Factors. Accessed June 9, 2025. <a href="https://www.cdc.gov/heart-disease/risk-factors/index.html" target="_blank" title="risk-factors" rel="noopener noreferrer">https://www.cdc.gov/heart-disease/risk-factors/index.html</a></p>
Simply purchase this test online. A healthcare provider will review and approve your test requests; no healthcare provider visit is required.
Visit a Labcorp location near you for sample collection. Visits may be scheduled online.
View your easy-to-read results online in your Labcorp Patient™ account, including Linked Accounts. For certain results that require prompt attention, you will also be contacted by phone or mail.
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The frequency of testing can vary based on individual health needs, health goals, risk factors, and any existing medical conditions. It's best to consult with your healthcare provider about the right testing frequency based on your unique health situation.
The results provide a detailed picture of various aspects of your cardiovascular health. They can help identify potential risk factors for heart disease and inform decisions about lifestyle changes or further medical interventions.
This expanded panel includes advanced biomarkers that provide more detailed information about cardiovascular risk than a standard lipid panel alone. It offers insights into inflammation, insulin resistance, and other factors that contribute to heart disease risk.
While this test cannot diagnose heart disease, it can help identify risk factors and guide preventive strategies or treatment options. Always consult with a healthcare professional to interpret your results and determine appropriate next steps.
While this panel focuses on blood biomarkers, other tests to assess heart function may include electrocardiograms (ECG), echocardiograms, and stress tests. Your healthcare provider can recommend the most appropriate tests based on your individual needs.
Your testing will be performed in a CLIA-certified clinical laboratory. Labcorp provides leading-edge medical laboratory tests and services through a national network of primary clinical laboratories and specialty testing laboratories. Our labs perform regular quality assurance testing to ensure our results are accurate.
Your results will be provided to you through our secure online portal to view or print. Results are also made available through a secure portal to the independent healthcare provider who placed your test order. If you are accessing your results through your Labcorp Patient™ account, all users linked to the account will have access to all OnDemand test results. Results may also be provided to a local, state, and/or federal health authority; for example, many states require the testing laboratory and physician to report test results for certain communicable diseases, such as COVID-19, to local or state health departments.
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Visit the Labcorp OnDemand® website to browse and purchase laboratory tests and create your Labcorp Patient™ account to view your results. All Labcorp OnDemand testing requires an order from an authorized healthcare professional. For your convenience, Labcorp OnDemand has contracted with independent professional entities (collectively, Providers) to deliver healthcare provider services. Visit a Labcorp location for sample collection; or, if using an at-home collection kit, collect your sample yourself. We’ll let you know when your results are ready and can be accessed through your Labcorp Patient™ account.
