Identify genetic markers linked to inherited celiac risk.
Celiac disease is an autoimmune condition in which eating gluten, a protein found in wheat, barley, and rye, causes the immune system to damage the lining of the small intestine. The Celiac HLA Genetic Test looks for specific variants of two genes, DQA1 and DQB1, which help produce the HLA-DQ2 and HLA-DQ8 proteins associated with celiac disease. These gene variants are commonly found in people with celiac disease but having them does not mean a person has or will develop the condition. If neither variant is detected, celiac disease is considered very unlikely.1
This test may help individuals better understand whether they carry genetic variants associated with celiac disease, particularly those with a family history of the condition or those discussing genetic testing with a healthcare provider.
Note: This test is not intended to diagnose, confirm, or predict future development of any condition. Results represent only one part of an overall health evaluation and should be reviewed with a healthcare professional or genetic counselor alongside personal health history, symptoms, and other laboratory findings.
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Preparation: No special preparation is needed before taking this test.
HLA-DQ2 and HLA-DQ8 are inherited genetic markers associated with celiac disease. However, many people with these markers never develop the condition. A positive result means one or more celiac-associated genetic markers were detected; it is not a diagnosis of the disease. A negative result indicates that these common celiac-associated genetic markers were not detected, making celiac disease very unlikely.
Digestive symptoms such as bloating, abdominal discomfort, or diarrhea can have many possible causes. Testing may provide insight into whether you carry genetic variants commonly associated with celiac disease and should be interpreted alongside other clinical information with a healthcare professional or genetic counselor.
If you've already removed gluten from your diet, traditional celiac blood tests may be less informative. HLA genetic testing looks for inherited genetic markers associated with celiac disease and may help clarify whether celiac disease is unlikely or should remain part of the conversation with your healthcare provider.
This test provides insight into whether you have a genetic risk for developing celiac disease. It’s appropriate for people with a family history of celiac disease or those interested in learning more about their genetic susceptibility.
1. Celiac HLA DQ association. Labcorp. Accessed August 23, 2026. https://www.labcorp.com/tests/167652/celiac-hla-dq-association
2. Meta-analysis and systematic review of HLA DQ2/DQ8 in adults with celiac disease. International Journal of Molecular Sciences. Published January 7, 2023. Accessed August 23, 2026. https://www.mdpi.com/1422-0067/24/2/1188
3. Gene test interpretation: HLA-DQ2 and HLA-DQ8 (celiac disease susceptibility genes). UpToDate. Updated August 7, 2025. Accessed August 23, 2026. https://www.uptodate.com/contents/gene-test-interpretation-hla-dq2-and-hla-dq8-celiac-disease-susceptibility-genes
4. Celiac disease. NIH Genetic Testing Registry. National Center for Biotechnology Information. Accessed August 23, 2026. https://www.ncbi.nlm.nih.gov/gtr/conditions/C0007570/
<p>1. Celiac HLA DQ association. Labcorp. Accessed August 23, 2026. <a rel="noopener noreferrer" title="celiac-hla-dq-association" target="_blank" href="https://www.labcorp.com/tests/167652/celiac-hla-dq-association">https://www.labcorp.com/tests/167652/celiac-hla-dq-association</a></p> <p>2. Meta-analysis and systematic review of HLA DQ2/DQ8 in adults with celiac disease. International Journal of Molecular Sciences. Published January 7, 2023. Accessed August 23, 2026. <a rel="noopener noreferrer" title="International Journal of Molecular Sciences" target="_blank" href="https://www.mdpi.com/1422-0067/24/2/1188">https://www.mdpi.com/1422-0067/24/2/1188</a></p> <p>3. Gene test interpretation: HLA-DQ2 and HLA-DQ8 (celiac disease susceptibility genes). UpToDate. Updated August 7, 2025. Accessed August 23, 2026. <a rel="noopener noreferrer" title="susceptibility-genes" target="_blank" href="https://www.uptodate.com/contents/gene-test-interpretation-hla-dq2-and-hla-dq8-celiac-disease-susceptibility-genes">https://www.uptodate.com/contents/gene-test-interpretation-hla-dq2-and-hla-dq8-celiac-disease-susceptibility-genes</a></p> <p>4. Celiac disease. NIH Genetic Testing Registry. National Center for Biotechnology Information. Accessed August 23, 2026. <a rel="noopener noreferrer" title="Biotechnology Information" target="_blank" href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C0007570/">https://www.ncbi.nlm.nih.gov/gtr/conditions/C0007570/</a></p>
Simply purchase this test online. A healthcare provider will review and approve your test requests; no healthcare provider visit is required.
Visit a Labcorp location near you for sample collection. Visits may be scheduled online.
View your easy-to-read results online in your Labcorp Patient™ account, including Linked Accounts. For certain results that require prompt attention, you will also be contacted by phone or mail.
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A celiac genetic test does not detect or diagnose celiac disease. Instead, it identifies whether you carry HLA-DQ2 or HLA-DQ8 gene variants, which are associated with increased genetic susceptibility. Results are most informative when reviewed alongside clinical history and other testing with a healthcare professional or genetic counselor.3
No single celiac disease test is right for every situation. Providers commonly begin with antibody blood testing while a person is eating gluten, such as Labcorp OnDemand’s Celiac Disease Antibody Test, and may recommend further evaluation based on the results. If you follow a gluten-free diet or previous results are unclear, a celiac genetic test like this one may provide added insight since your genes do not change with your diet.
Possible signs of celiac disease include4:
Some people have mild symptoms, symptoms outside the digestive system, or no noticeable symptoms. Because these concerns can have many causes, symptoms alone cannot determine whether someone has celiac disease.
HLA testing for celiac disease is a genetic test that looks for HLA-DQ2 and HLA-DQ8 variants associated with celiac disease. This test may be considered for people who follow a gluten-free diet, have had unclear previous test results, or have a family history of celiac disease. Because this test looks at inherited genetic markers, results are not affected by whether you are currently eating gluten. The test provides information about genetic susceptibility to celiac disease, but it does not diagnose celiac disease by itself.1
A positive result means that an HLA-DQ2 or HLA-DQ8 variant associated with celiac disease susceptibility was detected. A negative result means these common celiac-associated variants were not detected, making celiac disease highly unlikely. Neither result should be used alone to diagnose or make healthcare decisions, so review your findings with a healthcare provider or genetic counselor alongside your symptoms, diet, family history, and other celiac testing results.
Your testing will be performed in a CLIA-certified clinical laboratory. Labcorp provides leading-edge medical laboratory tests and services through a national network of primary clinical laboratories and specialty testing laboratories. Our labs perform regular quality assurance testing to ensure our results are accurate.
Your results will be provided to you through our secure online portal to view or print. Results are also made available through a secure portal to the independent healthcare provider who placed your test order. If you are accessing your results through your Labcorp Patient™ account, all users linked to the account will have access to all OnDemand test results. Results may also be provided to a local, state, and/or federal health authority; for example, many states require the testing laboratory and physician to report test results for certain communicable diseases, such as COVID-19, to local or state health departments.
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Visit the Labcorp OnDemand® website to browse and purchase laboratory tests and create your Labcorp Patient™ account to view your results. All Labcorp OnDemand testing requires an order from an authorized healthcare professional. For your convenience, Labcorp OnDemand has contracted with independent professional entities (collectively, Providers) to deliver healthcare provider services. Visit a Labcorp location for sample collection; or, if using an at-home collection kit, collect your sample yourself. We’ll let you know when your results are ready and can be accessed through your Labcorp Patient™ account.
To align with clinical best practices, we’ve set an age maximum of 100 for consumer-initiated testing. This limit was set to encourage individuals in more advanced age groups - who may have complex medical needs - to receive personalized guidance about testing from their healthcare providers.
