All Tests, General Health, Hormones, Women's Health, cleaneve tests
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Thyroid Peroxidase (TPO) Antibody Test

Measure TPO antibodies for insights into your thyroid health.

The thyroid peroxidase (TPO) antibody test measures the level of thyroid peroxidase antibodies in your blood. The immune system produces these antibodies if it mistakenly attacks the thyroid gland. This can lead to autoimmune thyroid disorders and other conditions. Elevated TPO antibodies are more commonly associated with Hashimoto’s thyroiditis, which causes hypothyroidism (an underactive thyroid), but they can also be present in Graves’ disease, which leads to hyperthyroidism (an overactive thyroid). These conditions can cause symptoms such as fatigue, weight changes, hair loss, irregular menstrual periods and mood changes. Some individuals without evidence of thyroid disease also have elevated TPO antibodies in their blood.

 

Testing for TPO antibodies can help you and your healthcare provider evaluate symptoms and conditions that may be related to an elevated TPO antibody level. TPO antibody is often evaluated in the context of other thyroid function tests such as thyroid-stimulating hormone (TSH), free T4 and free T3 to gain a full picture of your thyroid health.

 

Note: A TPO antibody test alone cannot assess how thyroid function.

 

 

$ 69.0
$69
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Thyroid Peroxidase (TPO) Antibody Test
$ 69.0
$69

Test Details

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Sample Type: Blood
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Collection Method: In person at a Labcorp location
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Age: 18+
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Results: Within 1-2 days from when your sample arrives at our lab
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HSA/FSA: Accepted
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Test must be taken by purchaser

Preparation: If you’re taking a supplement containing biotin (also called vitamin B7 or B8, vitamin H, or coenzyme R), commonly found in products promoting nail, skin and hair health, it is recommended that you wait at least 72 hours from your last dose before sample collection.

What's Tested
  • Thyroid peroxidase (TPO) antibody

    Thyroid peroxidase (TPO) antibody is a protein produced by the immune system that targets thyroid peroxidase, an enzyme needed for thyroid hormone production. This test measures the level of TPO antibodies in the blood. Elevated TPO antibody levels are often associated with autoimmune disorders such as Hashimoto’s thyroiditis and Graves’ disease but can be related to other conditions. These antibodies can indicate an ongoing immune response against the thyroid, potentially leading to inflammation and impaired thyroid function. Elevated TPO antibody levels may contribute to symptoms such as fatigue, weight gain, mood changes and irregular menstrual periods if thyroid function is abnormal. Some individuals will have elevated TPO antibodies without any evidence of a thyroid disorder.

Why Consider This Test

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Understand root cause of thyroid symptoms

If you’re experiencing symptoms such as fatigue, weight gain or mood changes, a TPO test may help you uncover if an autoimmune disorder such as Hashimoto’s thyroiditis or Graves’ disease could be affecting your thyroid function.

If you’re experiencing symptoms such as fatigue, weight gain or mood changes, a TPO test may help you uncover if an autoimmune disorder such as Hashimoto’s thyroiditis or Graves’ disease could be affecting your thyroid function.

In the U.S., Hashimoto’s thyroiditis is the most common cause of hypothyroidism, which occurs when the thyroid gland does not produce enough thyroid hormones. It often runs in families and is more common in women but can also affect men. Although it becomes more common with age, it can occur at any stage of life.1

Graves’ disease is an autoimmune disease that causes hyperthyroidism, a condition in which the thyroid gland makes too many hormones. It is the most common cause of hyperthyroidism in the U.S. It is more common in women and is linked to other autoimmune problems like Type 1 diabetes, rheumatoid arthritis and pernicious anemia (vitamin B12 deficiency).2

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Early detection and proactive prevention

Detecting high levels of thyroid peroxidase antibodies early can help you and your healthcare provider proactively manage conditions like Hashimoto’s disease and Graves’ disease and make informed decisions about your health.

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Get a full picture of your thyroid health

A TPO antibody test, when combined with other tests such as TSH, free T4 and free T3, can give a more comprehensive understanding of your thyroid health. A TPO test may help reveal autoimmune thyroid conditions that other thyroid tests do not detect.

References:

1. American Thyroid Association. Hashimoto’s Thyroiditis. Accessed October 9, 2024. https://www.thyroid.org/hashimotos-thyroiditis.

2. American Thyroid Association. Graves’ Disease. Accessed October 9, 2024. https://www.thyroid.org/graves-disease.

How It Works

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Purchase Your Test

Simply purchase this test online. A healthcare provider will review and approve your test requests; no healthcare provider visit is required.

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Provide Your Sample

Visit a Labcorp location near you for sample collection. Visits may be scheduled online.

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Get Your Results

View your easy-to-read results online in your Labcorp Patient™ account, including Linked Accounts. For certain results that require prompt attention, you will also be contacted by phone or mail.

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Frequently Bought Together

FAQ

  • A TPO test is used to detect presence of thyroid peroxidase antibodies in the blood, which can suggest an autoimmune thyroid disorder. Understanding TPO levels can help identify autoimmune conditions like Hashimoto’s thyroiditis or Graves’ disease, where the immune system mistakenly attacks the thyroid gland, potentially leading to thyroid dysfunction. This TPO antibody test is often ordered alongside TSH, free T4 and free T3 when individuals experience symptoms of hypothyroidism or hyperthyroidism.

  • Thyroid peroxidase (TPO) levels indicate the presence of antibodies against the thyroid peroxidase enzyme, which is essential for thyroid hormone production. Elevated TPO antibody levels may suggest an autoimmune response against the thyroid, often associated with conditions such as Hashimoto’s thyroiditis or Graves’ disease. High TPO antibody levels may also indicate ongoing inflammation or damage to the thyroid, which may lead to hypothyroidism or hyperthyroidism. However, TPO antibody levels alone do not determine thyroid function. Thyroid function tests, such as TSH and free T4 are needed to assess thyroid activity.
     

    Note: This test does not diagnose or determine the cause of thyroid-related conditions. It is recommended to consult with a healthcare provider if you have any questions about your result.

  • Your testing will be performed in a CLIA-certified clinical laboratory. Labcorp provides leading-edge medical laboratory tests and services through a national network of primary clinical laboratories and specialty testing laboratories. Our labs perform regular quality assurance testing to ensure our results are accurate.

  • Your results will be provided to you through our secure online portal to view or print. Results are also made available through a secure portal to the independent healthcare provider who placed your test order.  If you are accessing your results through your Labcorp Patient™ account, all users linked to the account will have access to all OnDemand test results. Results may also be provided to a local, state, and/or federal health authority; for example, many states require the testing laboratory and physician to report test results for certain communicable diseases, such as COVID-19, to local or state health departments.

     

    If you have questions or comments regarding the Labcorp Notice of Privacy Practices, or have a complaint about our use or disclosure of your PHI or our privacy practices, please contact: privacyofficer@labcorp.com, call us at (877) 234-4722 (877-23-HIPAA) and ask for the Labcorp HIPAA Privacy Officer, or send a written request to: HIPAA Privacy Officer, Labcorp, 531 South Spring Street, Burlington, NC 27215. You also may file a complaint with the Secretary of the U.S. Department of Health and Human Services.

  • Visit the Labcorp OnDemand® website to browse and purchase laboratory tests and create your Labcorp Patient™ account to view your results. All Labcorp OnDemand testing requires an order from an authorized healthcare professional. For your convenience, Labcorp OnDemand has contracted with independent professional entities (collectively, Providers) to deliver healthcare provider services. Visit a Labcorp location for sample collection; or, if using an at-home collection kit, collect your sample yourself. We’ll let you know when your results are ready and can be accessed through your Labcorp Patient™ account.

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